Purification and characterization of an organ specific haemorrhagic toxin from Vipera russelli russelli (Russell's viper) venom.

Enzymatic activity and inhibition of the neurotoxic complex vipoxin from the venom of Vipera ammodytes meridionalis.

Vipoxin from the venom of Vipera ammodytes meridionalis is an unique neurotoxic complex between a toxic phospholipase A2 and a highly homologous non-toxic protein inhibitor. It is an example of evolution of a catalytic and toxic function into inhibitory and non-toxic one. The activity of the V. ammodytes meridionalis toxin is 1.7 times higher than that of the closely related (92% sequence ident...

Toxoiding of snake venom and evaluation of immunogenicity of the toxoids.

The venom of Pakistan species of snakes (Naja naja, Vipera russelli and Echis carinatus) and lethal fractions of Cobra (Naja naja) venom were converted to toxoid with formalin. Detoxification of the crude venoms and toxic fraction was attained by addition of formalin in several steps and incubation at 37°C maintaining the pH 7.0. Relationship of formalin concentration and incubation period was ...

Plasma clearance time of Russell's viper (Vipera russelli) antivenom in human snake bite victims.

Morphology coagulation studies in guinea pigs following injection of vipera russelli venom.

The studies on the morphology of lesions produced and the blood coagulation disturbances after Russell viper envenomation were studied in guinea pigs. The study showed very little morphological changes but the coagulation studies revealed disturbances in coagulation mechanism. The exact pathological process operating in Russell viper emvenomation needs further studies including the histochemica...

Active compound from the leaves of Vitex negundo L. shows anti-inflammatory activity with evidence of inhibition for secretory Phospholipase A2 through molecular docking

Novel compounds with significant medicinal properties have gained much interest in therapeutic approaches for treating various inflammatory disorders like arthritis, odema and snake bites and the post-envenom (impregnating with venom) consequences. Inflammation is caused by the increased concentration of secretory Phospholipases A(2) (sPLA(2)s) at the site of envenom. A novel compound Tris(2,4-...